Z-DEVD-FMK

Caspase-3 is a cysteinyl aspartate-specific protease which plays a central role in apoptosis. Z-DEVD-FMK is a cell-permeable irreversible inhibitor of caspase-3 (IC50 = 130 nM). It potently inhibits apoptosis.Formal Name: N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester. CAS Number: 210344-95-9. Molecular Formula: C30H41FN4O12. Formula Weight: 668.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. SMILES: O=C(N[C@@H](CC(OC)=O)C(N[C@@H](CCC(OC)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(OC)=O)C(CF)=O)=O)=O)=O)OCC1=CC=CC=C1. InChi Code: InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1. InChi Key: GBJVAVGBSGRRKN-JYEBCORGSA-N.