YZ9

Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs. During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction as fructose 2,6-bisphosphatases, these enzymes are known as PFKFB family members. Notably, PFKFB3 is overexpressed in a wide variety of cancer cell lines. YZ9 is a potent inhibitor of PFKFB3, with an IC50 value of 183 nM in vitro. It avidly competes with F6P at PFKFB3 (Ki = 94 nM). YZ9 is also cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM.Formal Name: 7-hydroxy-2-ozo-2H-1-benzopyran-3-carboxylic acid, ethyl ester. CAS Number: 6093-71-6. Synonyms: 7-hydroxycoumarin-3-Carboxylic Acid ethyl ester. Molecular Formula: C12H10O5. Formula Weight: 234.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 348 nm. SMILES: O=C1C(C(OCC)=O)=CC2=CC=C(O)C=C2O1. InChi Code: InChI=1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3. InChi Key: IETDBZQIWIJQJG-UHFFFAOYSA-N.