YLL545

Description: YLL545 is an inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2). It inhibits VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling mediators (such as phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC). Additionally, YLL545 suppresses HUVEC proliferation, migration, invasion, and angiogenesis. It also induces apoptosis and inhibits tumor growth in a mouse model of breast cancer. Target: Apoptosis, VEGFR, ERK, STAT. Smiles: O=C(NC1=CC=C(OC2=NC=NC=3NN=CC23)C=C1)NC4=CC=CC(=C4)C(F)(F)F