Y-33075

Y-33075 is an inhibitor of Rho-associated kinase 2 (ROCK2, IC50 = 3.6 nM). It is selective for ROCK2 over PKC and calcium/calmodulin-dependent protein kinase II (CaMKII, IC50s = 420 and 810 nM, respectively). Topical application of Y-33075 (0.05% v/v) reduces intraocular pressure in rabbit and cynomolgus monkeys. Y-33075 (10 and 100 µM) increases axonal regeneration at the crush site in a cat model of surgically-induced optic nerve damage. It also inhibits demyelination and reduces the incidence of relapse episodes in a mouse model of chronic relapsing experimental autoimmune encephalomyelitis (EAE).Formal Name: 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide. CAS Number: 199433-58-4. Synonyms: RKI-983, SNJ-1656, Y-39983. Molecular Formula: C16H16N4O. Formula Weight: 280.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1=CC=C(C=C1)[C@H](N)C)NC2=C3C(NC=C3)=NC=C2. InChi Code: InChI=1S/C16H16N4O/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15/h2-10H,17H2,1H3,(H2,18,19,20,21)/t10-/m1/s1. InChi Key: JTVBXQAYBIJXRP-SNVBAGLBSA-N.