Y-26763

Y-26763 is an activator of ATP-sensitive potassium (KATP) channels. It increases the frequency of KATP channel openings in the presence of ATP and activates KATP channel currents in isolated human beta-cells when used at a concentration of 200 µM. It also inhibits increases in intracellular calcium induced by histamine or norepinephrine (Cay-16673) in isolated rabbit mesenteric artery smooth muscle in a concentration-dependent manner. Y-26763 induces relaxation in isolated precontracted rat aortic rings (IC50 = 0.027 µM). It decreases mean blood pressure in spontaneously hypertensive rats when administered intravenously at a dose of 0.03 mg/kg, an effect that can be reversed by glibenclamide (Cay-15009).Formal Name: N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy-acetamide. CAS Number: 127408-31-5. Molecular Formula: C14H16N2O4. Formula Weight: 276.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. lambdamax: 253, 290 nm. SMILES: O[C@H]1[C@H](N(C(C)=O)O)C2=CC(C#N)=CC=C2OC1(C)C. InChi Code: InChI=1S/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1. InChi Key: IWTCFIIOUXJOOV-OLZOCXBDSA-N.