XTT (sodium salt hydrate)

Description: XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator [1,2]. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis [3]. Smiles: O.[Na+].COc1cc(c(cc1-n1nc(n[n+]1-c1cc(c(cc1OC)[N+]([O-])=O)S([O-])(=O)=O)C(=O)Nc1ccccc1)S([O-])(=O)=O)[N+]([O-])=O. References: Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005)