Xite(TM) Green beta-D-galactopyranoside

Xite(TM) Green beta-D-galactopyranoside is a fluorogenic substrate for beta-galactosidase (beta-gal). Compared to the existing beta-galactosidase substrates (e.g., the commonly used FDG), it has much better cell permeability. Xite(TM) Green beta-D-galactopyranoside readily enters cells where it gets cleaved by beta-gal, producing Xite(TM) Green, a strongly fluorescent product. The strongly fluorescent Xite(TM) Green is well retained in cells, making it easy to be detected with a flow cytometer and fluorescence microscope. Xite(TM) Green beta-D-galactopyranoside provides a simple and sensitive tool to detect beta-galactosidase activity. Xite(TM) Green beta-D-galactopyranoside might be used as a simple tool for measuring cellular senescence in cells since beta-gal has been identified as a reliable marker for cellular senescence.