WZB117

WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels. It inhibits cancer cell proliferation (IC50s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis or apoptosis. These effects are enhanced by the anticancer drugs cisplatin (Cay-13119) and paclitaxel (Cay-10461). WZB117, given intraperitoneally at 10 mg/kg, significantly reduces tumor size in mice, with only small reductions in body weight and leukocyte count. WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.Formal Name: 3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester. CAS Number: 1223397-11-2. Synonyms: Glucose Transporter Inhibitor IV. Molecular Formula: C20H13FO6. Formula Weight: 368.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 212, 242, 305 nm. SMILES: OC1=CC=CC(C(OC2=CC=CC(F)=C2OC(C3=CC(O)=CC=C3)=O)=O)=C1. InChi Code: InChI=1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H. InChi Key: FRSWCCBXIHFKKY-UHFFFAOYSA-N.