Wedelolactone

Yellow to amber crystalline powder. Soluble in DMSO or methanol. Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor, NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha, Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor, Anti-inflammatory, HIV-1 integrase inhibitor, Anticancer and antiproliferative compound, Modulates androgen receptor (AR) activation, Apoptosis inducer via downregulation of PKCepsilon, DNA topoisomerase IIalpha inhibitor, G protein-coupled receptor-35 (GPR35) agonist, Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway, STAT1 protein dephosphorylation inhibitor, Antifibrotic.