WAY-262611

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Dickkopf-1 (Dkk1) antagonizes Wnt signaling and has important roles in bone formation, cancer, and Alzheimer's disease. WAY-262611 is an inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating beta-catenin/TCF-dependent transcription with an EC50 value of 0.63 µM. It has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration. WAY-262611 has been used to elucidate the role of Dkk1 in modulating Wnt signaling, particularly in the context of arthritis.Formal Name: 1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine. CAS Number: 1123231-07-1. Synonyms: BML-WN110, Dickkopf-1 Inhibitor, Dkk1 Inhibitor. Molecular Formula: C20H22N4. Formula Weight: 318.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 226, 256, 338 nm. SMILES: NCC1CCN(C2=NC(C3=CC(C=CC=C4)=C4C=C3)=CC=N2)CC1. InChi Code: InChI=1S/C20H22N4/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18/h1-7,10,13,15H,8-9,11-12,14,21H2. InChi Key: QHLITPHIARVDJI-UHFFFAOYSA-N.