W-7 (hydrochloride)

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 µM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 µM, respectively).Formal Name: N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, monohydrochloride. CAS Number: 61714-27-0. Synonyms: NSC 683545. Molecular Formula: C16H21ClN2O2S . HCl. Formula Weight: 377.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 14 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 224, 297 nm. SMILES: ClC1=C(C=CC=C2S(NCCCCCCN)(=O)=O)C2=CC=C1.Cl. InChi Code: InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18,/h5-10,19H,1-4,11-12,18H2,1H. InChi Key: OMMOSRLIFSCDBL-UHFFFAOYSA-N.