VUF11211

Description: VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains. Target: Others. Smiles: C(C)[C@@H]1N(CCN(C1)C2=C(Cl)C=C(C(NCC)=O)C=N2)C3CCN(CC4=CC=C(Cl)C=C4)CC3. References: Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Jöhrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN. Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors. Haematologica. 2016 Mar,101(3):e99-102. doi: 10.3324/haematol.2015.133470. Epub 2015 Nov 20. PubMed PMID: 26589908, PubMed Central PMCID: PMC4815737.