VU6036720 (hydrochloride)

VU6036720 is an inhibitor of heteromeric inward-rectifier potassium channels (Kir) composed of Kir4.1 and Kir5.1 subunits (IC50 = 0.24 µM). It is selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv11.1, also known as human ether-a-go-go (hERG, IC50 = 6.4 µM). VU6036720 (30 and 100 mg/kg) does not inhibit diuresis in mice due to low oral bioavailability and high hepatic clearance.Formal Name: (S)-3-chloro-N-(2-(4-(2-cyanophenyl)-2-methylpiperazin-1-yl)ethyl)-4-fluorobenzenesulfonamide, monohydrochloride. Molecular Formula: C20H22ClFN4O2S . HCl. Formula Weight: 473.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble, DMSO: Soluble, Water: Slightly Soluble. SMILES: O=S(C1=CC=C(F)C(Cl)=C1)(NCCN2CCN(C3=CC=CC=C3C#N)C[C@@H]2C)=O.Cl. InChi Code: InChI=1S/C20H22ClFN4O2S.ClH/c1-15-14-26(20-5-3-2-4-16(20)13-23)11-10-25(15)9-8-24-29(27,28)17-6-7-19(22)18(21)12-17,/h2-7,12,15,24H,8-11,14H2,1H3,1H/t15-,/m0./s1. InChi Key: ZRUTWJFQZLMEBJ-RSAXXLAASA-N.