VU590 (hydrochloride)

KCNJ1 (Kir1.1, or renal outer medullary potassium channel) and KCNJ13 (Kir7.1) are inwardly rectifying two-transmembrane K+ channels. KCNJ1 has critical roles in kidney function, while KCNJ13 is important in the eye, kidney, and small intestine. VU590 is a small molecule inhibitor of KCNJ1 (IC50 = 294 nM) which also causes 70% inhibition of KCNJ13 at 10 µM. It has no effect on the related channels KCNJ2 (Kir2.1) and KCNJ10 (Kir4.1) at a concentration of 10 µM.Formal Name: 7,13-bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane, dihydrochloride. CAS Number: 1783987-83-6. Synonyms: CID-4536383, ML-111. Molecular Formula: C24H32N4O7 . 2HCl. Formula Weight: 561.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Water: 10 mg/ml. lambdamax: 259, 350 nm. SMILES: O=[N+](C(C=C1)=CC=C1CN2CCOCCOCCN(CCOCC2)CC3=CC=C([N+]([O-])=O)C=C3)[O-].Cl.Cl. InChi Code: InChI=1S/C24H32N4O7.2ClH/c29-27(30)23-5-1-21(2-6-23)19-25-9-13-33-14-10-26(12-16-35-18-17-34-15-11-25)20-22-3-7-24(8-4-22)28(31)32,,/h1-8H,9-20H2,2*1H. InChi Key: FRYYSUBAHIUBNJ-UHFFFAOYSA-N.