Viridicatol

Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. It also inhibits NF-kappaB DNA-binding activity, nuclear translocation of NF-kappaB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B alpha (IkappaBalpha) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay. It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 µM).Formal Name: 3-hydroxy-4-(3-hydroxyphenyl)-2(1H)-quinolinone. CAS Number: 14484-44-7. Molecular Formula: C15H11NO3. Formula Weight: 253.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C1C(O)=C(C2=CC(O)=CC=C2)C3=CC=CC=C3N1. InChi Code: InChI=1S/C15H11NO3/c17-10-5-3-4-9(8-10)13-11-6-1-2-7-12(11)16-15(19)14(13)18/h1-8,17-18H,(H,16,19). InChi Key: QIJIOTTYIGBOQA-UHFFFAOYSA-N.