VH 032 Linker 1

VH 032 linker 1 is a precursor in the synthesis of the proteolysis-targeting chimeras (PROTACs) that contain a terminal amine conjugated via a PEG linker to VHL ligand 1 (Cay-21591), which binds to VHL E3 ligase. It has been used in the synthesis of PROTACs targeting TEA domain transcription factors (TEADs) in cancer cells.Formal Name: (4R)-N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, monohydrochloride. CAS Number: 2097971-11-2. Molecular Formula: C30H45N5O7S . HCl. Formula Weight: 656.2. Purity: >95%. Formulation: (Request formulation change), A solid. lambdamax: 272 nm. SMILES: O=C([C@@H](NC(COCCOCCOCCN)=O)C(C)(C)C)N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O.Cl. InChi Code: InChI=1S/C30H45N5O7S.ClH/c1-20-26(43-19-33-20)22-7-5-21(6-8-22)16-32-28(38)24-15-23(36)17-35(24)29(39)27(30(2,3)4)34-25(37)18-42-14-13-41-12-11-40-10-9-31,/h5-8,19,23-24,27,36H,9-18,31H2,1-4H3,(H,32,38)(H,34,37),1H/t23-,24+,27-,/m1./s1. InChi Key: ZOYHUTRHKHRRPK-QVRKWNSCSA-N.