VEGFR/PARP-IN-1

Description: VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. This compound demonstrates considerable antiproliferative activity against BRCA wild-type breast cancer cells, with IC50 values of 4.1 µM for MDA-MB-231 cells and 3.5 µM for MCF-7 cells, indicating its potential as an antitumor and anti-metastasis agent [1]. Target: PARP