Usnic Acid

Usnic acid is a lichen metabolite with antioxidant, anticancer, antifungal, antiprotozoal, and antimicrobial activities. Usnic acid (>50 mg/kg) reduces the number of indomethacin-induced gastric ulcers in rats through decreased lipid peroxidation and decreased myeloperoxidase activity. It is fungicidal against C. orthopsilosis and C. parapsilosis (IC80s = 7.8 and 15.6 µg/ml, respectively) and bactericidal against seven vancomycin-resistant E. faecalis strains (MIC = 125 µg/ml). Usnic acid (25 mg/kg, injected intralesionally) reduces L. amazonensis parasite loads by 72.3% in footpads of infected mice. It also reduces growth of A2780, HeLa, MCF-7, SK-BR-3, HT-29, HCT116, HL-60, and Jurkat cancer cells in vitro (IC50s = 48.5-199 µM).Formal Name: 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione. CAS Number: 125-46-2. Synonyms: NSC 8517. Molecular Formula: C18H16O7. Formula Weight: 344.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMF:PBS (pH7.2) (1:40): 0.02 mg/ml. lambdamax: 233, 282 nm. SMILES: CC1(C(C2C(C)=O)=O)C3=C(O)C(C)=C(O)C(C(C)=O)=C3OC1=CC2=O. InChi Code: InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,11,22-23H,1-4H3. InChi Key: CUCUKLJLRRAKFN-UHFFFAOYSA-N.