Unifiram

Unifiram is a nootropic agent. It increases acetylcholine (ACh) release in the rat cerebral cortex in vivo and induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50 = 27 nM). It does not bind to serotonin (5-HT), dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, or GABA receptors at 1 µM. Unifiram (0.1 mg/kg) improves memory in non-memory-impaired rats in a social learning test. It also prevents memory deficits induced by the anticholinergic agent scopolamine, nicotinic receptor antagonist mecamylamine, GABAB receptor agonist baclofen, or alpha2-adrenergic receptor agonist clonidine in the passive avoidance test in mice when administered at a dose of 0.01 mg/kg and prevents memory deficits induced by the AMPA/kainate glutamate receptor antagonist NBQX at 0.1 mg/kg.Formal Name: 2-[(4-fluorophenyl)sulfonyl]hexahydro-pyrrolo[1,2-a]pyrazin-6(2H)-one. CAS Number: 272786-64-8. Synonyms: DM232. Molecular Formula: C13H15FN2O3S. Formula Weight: 298.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 1 mg/ml. lambdamax: 223 nm. SMILES: O=C1N2CCN(S(=O)(C3=CC=C(C=C3)F)=O)CC2CC1. InChi Code: InChI=1S/C13H15FN2O3S/c14-10-1-4-12(5-2-10)20(18,19)15-7-8-16-11(9-15)3-6-13(16)17/h1-2,4-5,11H,3,6-9H2. InChi Key: SNRTZFZAFBIBJP-UHFFFAOYSA-N.