UCM53

UCM53 is an inhibitor of bacterial cell division. It binds to the GTP site of the cell division protein FtsZ from B. subtilis in a fluorescent anisotropy assay. In B. subtilis, UCM53 (3 µM) reduces the number of FtsZ rings and increases the number of foci, as well as induces filamentation when used at a concentration of 12 µM. It is active against laboratory strains and clinical isolates of the Gram-positive bacteria B. subtilis, S. aureus, E. faecium, and E. faecalis (MICs = 2-8 mg/L) but is less effective against S. pneumoniae and the Gram-negative bacteria P. aeruginosa, E. coli, and K. pneumoniae (MICs = 32-128 mg/L). UCM53 inhibits cell growth in a panel of cancerous (IC50s = 16.9-76.5 mg/L) and non-cancerous mammalian cell lines (IC50s = 23.5-93.9 mg/L).Formal Name: naphthalene-1,3-diyl bis(3-chloro-4-hydroxybenzoate). CAS Number: 2468847-23-4. Molecular Formula: C24H14Cl2O6. Formula Weight: 469.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 266 nm. SMILES: ClC1=C(O)C=CC(C(OC2=CC(C=CC=C3)=C3C(OC(C4=CC(Cl)=C(O)C=C4)=O)=C2)=O)=C1. InChi Code: InChI=1S/C24H14Cl2O6/c25-18-10-14(5-7-20(18)27)23(29)31-16-9-13-3-1-2-4-17(13)22(12-16)32-24(30)15-6-8-21(28)19(26)11-15/h1-12,27-28H. InChi Key: GWBTWBNCPASUNW-UHFFFAOYSA-N.