UAMC-3203

UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells. It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 (Cay-17729). In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.Formal Name: 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-N-[2-(1-piperazinyl)ethyl]-benzenesulfonamide. CAS Number: 2271358-64-4. Molecular Formula: C25H37N5O2S. Formula Weight: 471.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: Soluble. lambdamax: 237, 286 nm. SMILES: O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O. InChi Code: InChI=1S/C25H37N5O2S/c31-33(32,28-15-18-30-16-13-26-14-17-30)23-11-12-24(29-22-9-5-2-6-10-22)25(19-23)27-20-21-7-3-1-4-8-21/h1,3-4,7-8,11-12,19,22,26-29H,2,5-6,9-10,13-18,20H2. InChi Key: HSYSVXKJIVUNBR-UHFFFAOYSA-N.