TWIK-1/TREK-1-IN-1

Description: Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of 9.36 µM for TREK-1 homodimers and 14.6 µM for TWIK-1/TREK-1 heterodimers, demonstrating antidepressant-like effects [1]. Target: Potassium Channel