TSI-01

Description: TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 µM and 3.02 µM for human LPCAT2 and LPCAT1, respectively). At 60 µM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages. Target: Others, PAFR. Smiles: O=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O