TRPM4-IN-5

TRPM4-IN-5 is an inhibitor of transient receptor potential melastatin 4 (TRPM4, IC50 = 1.5 µM in HEK293 cells expressing TRPM4). It is selective for TRPM4 over TRPM5 at 10 µM and TRPM7, TRPM8, transient receptor potential vanilloid 1 (TRPV1), and TRPV6 at 100 µM, as well as a panel of 17 other ion channels and receptors at 10 µM. TRPM4-IN-5 (50 µM) inhibits persistent firing in isolated mouse thalamic slices stimulated with the small conductance calcium-activated potassium channel (KCa2.2/SK2) inhibitor apamin (Cay-17082).Formal Name: 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-benzoic acid. CAS Number: 351424-20-9. Synonyms: CBA, Transient Receptor Potential Melastatin 4 Inhibitor 5, TRPM4 Inhibitor 5. Molecular Formula: C15H11Cl2NO4. Formula Weight: 340.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 230, 256 nm. SMILES: O=C(C1=C(NC(COC2=C(Cl)C=CC=C2)=O)C=C(Cl)C=C1)O. InChi Code: InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21). InChi Key: CVQCJPCMPGKEDH-UHFFFAOYSA-N.