Triptolide

Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities. It inhibits dCTP pyrophosphatase 1 (Ki = 168 µM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis. It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human non-small cell lung cancer (NSCLC) cells when used at a concentration of 50 nM. Intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer. Triptolide (0.2 mg/kg) reduces intestinal inflammation and prevents colon shortening in a mouse model of colitis induced by dextran sulfate (Cay-23250). It also inhibits skin allograft rejection and increases graft survival time in mice when administered at a dose of 0.1 mg/kg per day post-transplantation.Formal Name: 3bS,4,4aS,6R,6aR,7aS,7bS,8bS,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5aS:6,7:8aS,9]phenanthro[1,2-c]furan-1(3H)-one. CAS Number: 38748-32-2. Synonyms: NSC 163062, PG 490. Molecular Formula: C20H24O6. Formula Weight: 360.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 217 nm. SMILES: C[C@@]12[C@]3([C@H]([C@H]4[C@]5(C(C)C)O4)O3)[C@@]([C@@H]5O)(O6)[C@@H]6C[C@@]1([H])C(COC7=O)=C7CC2. InChi Code: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1. InChi Key: DFBIRQPKNDILPW-CIVMWXNOSA-N. Origin: Plant/Tripterygium wilfordii.