Trihexyphenidyl (hydrochloride)

Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine (Cay-23829) in guinea pig ileum (IC50 = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson's disease.Formal Name: alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanol, monohydrochloride. CAS Number: 52-49-3. Synonyms: Benzhexol hydrochloride. Molecular Formula: C20H31NO . HCl. Formula Weight: 337.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 3 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. SMILES: OC(CCN1CCCCC1)(C2=CC=CC=C2)C3CCCCC3.Cl. InChi Code: InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21,/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2,1H. InChi Key: QDWJJTJNXAKQKD-UHFFFAOYSA-N.