TRC051384

Description: TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells. Target: HSP. Smiles: O=C(NCCN1CCOCC1)Nc1ccc(cc1)C(=O)\C=C\c1cccc(n1)N1CCOCC1. References: Mohanan A, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May,60(6):991-9.