Traxoprodil

Description: Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). Target: NMDAR, iGluR. Smiles: OC1(CCN([C@H]([C@@H](O)C2=CC=C(O)C=C2)C)CC1)C3=CC=CC=C3. References: Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4,38(16):3138-45.