trans-Indole-3-acrylic Acid

trans-Indole-3-acrylic acid is a metabolite of the essential amino acid L-tryptophan (Cay-29600). It is formed from tryptophan by gut microbiota. trans-Indole-3-acrylic acid (100 µM) increases the levels of mRNA encoding mucin 2 and Il-10, as well as decreases mRNA encoding Tnf-alpha, in primary mouse large intestinal spheroids co-cultured with LPS-stimulated primary mouse bone marrow-derived macrophages (BMDMs). It has been used as a precursor in the synthesis of anticancer agents and tubulin polymerization inhibitors, as well as used as a reactive chromophore probe to assess the alpha and beta subunit conformational changes of S. typhimurium tryptophan synthase in tryptophan biosynthesis.Formal Name: 3-(1H-indol-3-yl)-2E-propenoic acid. CAS Number: 29953-71-7. Synonyms: IA, trans-3-Indoleacrylic acid. Molecular Formula: C11H9NO2. Formula Weight: 187.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: O=C(O)/C=C/C1=CNC2=CC=CC=C21. InChi Code: InChI=1S/C11H9NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-7,12H,(H,13,14)/b6-5+. InChi Key: PLVPPLCLBIEYEA-AATRIKPKSA-N.