trans-AUCB

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. trans-AUCB is a very potent inhibitor of sEH (IC50 = 0.5 nM). It displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg. Dual inhibition of COX-2 and sEH, by celecoxib (Cay-10008672) and trans-AUCB, suppresses tumor angiogenesis, inhibiting tumor growth and metastasis in a Lewis lung carcinoma model in mice.Formal Name: 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid. CAS Number: 885012-33-9. Molecular Formula: C24H32N2O4. Formula Weight: 412.5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 256 nm. SMILES: O=C(O)C(C=C1)=CC=C1O[C@H]2CC[C@H](NC(NC34C[C@H]5C[C@H](C[C@H](C5)C4)C3)=O)CC2. InChi Code: InChI=1S/C24H32N2O4/c27-22(28)18-1-5-20(6-2-18)30-21-7-3-19(4-8-21)25-23(29)26-24-12-15-9-16(13-24)11-17(10-15)14-24/h1-2,5-6,15-17,19,21H,3-4,7-14H2,(H,27,28)(H2,25,26,29)/t15-,16+,17-,19-,21-,24?. InChi Key: KNBWKJBQDAQARU-GVVVSFATSA-N.