Tolvaptan-d7

Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Cay-19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC50 = 0. µM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0. mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction. Formulations containing tolvaptan have been used to treat hyponatremia. InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)/i1D3,3D,4D,6D,7D, InChIKey: GYHCTFXIZSNGJT-FFQSSJIFSA-N, SMILES: O=C(NC1=CC(C)=C(C(N2C(C=CC(Cl)=C3)=C3C(O)CCC2)=O)C=C1)C4=C(C([2H])([2H])[2H])C([2H])=C([2H])C([2H])=C4[2H]