TNF-alpha-IN-2

An inhibitor of TNF-alpha, inhibits TNF-alpha-induced secretion of a SEAP reporter in HEK-Blue cells (IC50 = 27 nM), reduces paw TNF-alpha, IL-1beta, and IL-6 levels and swelling in a mouse model of alpha-collagen antibody-induced arthritis. SMILES: C[C@H](C1=CC(C#N)=CC=C1F)NC2=C(Cl)C(C)=NC3=C2N=C(C4=CN=C(C(C)(O)C)N=C4)C(F)=C3. InChi Code: InChI=1S/C25H21ClF2N6O/c1-12(16-7-14(9-29)5-6-17(16)27)33-23-20(26)13(2)32-19-8-18(28)21(34-22(19)23)15-10-30-24(31-11-15)25(3,4)35/h5-8,10-12,35H,1-4H3,(H,32,33)/t12-/m1/s1. InChi Key: UDLNDXDUOBMZIQ-GFCCVEGCSA-N