TMX-4116

TMX-4116 is a casein kinase 1alpha (CK1alpha) degrader. It selectively induces E3 ubiquitin ligase-mediated degradation of CK1alpha over phosphodiesterase 6D (PDE6D), Ikaros family zinc finger protein 1 (IKZF1), and IKZF3 in MM.1S cells when used at concentrations ranging from 0.04 to 1 µM. SMILES COC1=C(SC=C1C2=CN(N=N2)C(C(N3)=O)CCC3=O)C(N4CCCC4)=O InChi Code InChI=1S/C17H19N5O4S/c1-26-14-10(9-27-15(14)17(25)21-6-2-3-7-21)11-8-22(20-19-11)12-4-5-13(23)18-16(12)24/h8-9,12H,2-7H2,1H3,(H,18,23,24) InChi Key OOIINFBRWZQRRM-UHFFFAOYSA-N