TMC207

TMC207 is a diarylquinoline that selectively inhibits the proton pump of the mycobacterial ATP synthase. It demonstrates potent activity against both drug-sensitive and drug-resistant M. tuberculosis and other mycobacterial species with MIC50 values of ~0.03 µg/ml.Formal Name: (alphaS,betaR)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol. CAS Number: 843663-66-1. Synonyms: Bedaquiline, R207910. Molecular Formula: C32H31BrN2O2. Formula Weight: 555.5. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 226, 275, 285, 318, 333 nm. SMILES: BrC1=CC(C=C([C@@H](C2=CC=CC=C2)[C@](CCN(C)C)(O)C3=CC=CC4=C3C=CC=C4)C(OC)=N5)=C5C=C1. InChi Code: InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1. InChi Key: QUIJNHUBAXPXFS-XLJNKUFUSA-N.