Tin(IV) Protoporphyrin IX Chloride

Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Cay-17161). While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. Tin(IV) protoporphyrin IX chloride is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). Tin(IV) protoporphyrin IX chloride prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. Tin(IV) protoporphyrin IX chloride is commonly used as a tool to study the role of HO-1 activity in cells and in animals.Formal Name: (OC-6-13)-dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24]-stannate(2-), dihydrogen. CAS Number: 14325-05-4. Synonyms: NSC 267099, SnPPIX. Molecular Formula: C34H30Cl2N4O4Sn . 2H. Formula Weight: 750.3. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 405, 541, 579 nm. SMILES: [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Sn+4]35([Cl-])([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]. InChi Code: InChI=1S/C34H34N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25,,,/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42),2*1H,/q,,,+4/p-4/b25-13-,26-. InChi Key: HDGCWLZQBOZSGG-UHEVNVKKSA-J.