Ticlopidine (hydrochloride)

Ticlopidine is a thienopyridine P2Y12 receptor antagonist. It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Cay-90010), and ADP (Cay-16778, IC50s = 75, 600, and 1,300 µM, respectively). It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg. Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats. Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.Formal Name: 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, monohydrochloride. CAS Number: 53885-35-1. Molecular Formula: C14H14ClNS . HCl. Formula Weight: 300.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: ClC1=C(CN2CCC(SC=C3)=C3C2)C=CC=C1.Cl. InChi Code: InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14,/h1-4,6,8H,5,7,9-10H2,1H. InChi Key: MTKNGOHFNXIVOS-UHFFFAOYSA-N.