Thymidylate Kinase Inhibitor, YMU1

Description: YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Target: Others. Smiles: O=C1C=2C(SN1CC(=O)N3CCN(C(OCC)=O)CC3)=NC(C)=CC2C. References: Dong B , Jaeger A M , Hughes P F , et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1[J]. Science Translational Medicine, 2020, 12(574):eabb5647.