Thonzonium Bromide

Description: Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 µM). It inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Target: Proton pump, Autophagy, Antibacterial. Smiles: [Br-].CCCCCCCCCC CCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1. References: Chan, C., Prudom, C., Raines, S., Charkhzarrin, S., Melman, S., & De Haro, L. et al. (2012). Inhibitors of V-ATPase Proton Transport Reveal Uncoupling Functions of Tether Linking Cytosolic and Membrane Domains of V 0 Subunit a (Vph1p). Journal Of Biological Chemistry, 287(13), 10236-10250. doi: 10.1074/jbc.m111.321133