Thiolutin

Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 µg/ml). Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.Formal Name: N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-acetamide. CAS Number: 87-11-6. Synonyms: Acetopyrrothin, NSC 3927. Molecular Formula: C8H8N2O2S2. Formula Weight: 228.3. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 1 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 310, 390 nm. SMILES: CC(NC1=C2C(N(C)C1=O)=CSS2)=O. InChi Code: InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11). InChi Key: MHMRAFONCSQAIA-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces luteosporeus.