Thiocolchicoside

Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist - Weak nicotinic acetylcholine receptor agonist - Muscle relaxant - Anti-inflammatory. Has analgesic properties - Shows strong epileptogenic and convulsant activity - Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products - Apoptosis inducer - Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway - Therapeutic option for the management of bone metastatic disease.