Thalidomide-O-PEG2-propargyl

Description: Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thalidomide, along with a 2-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes ligand-induced protein degradation [1]. Target: Others. Smiles: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCOCCOCC#C)C3C2=O)CC1. References: Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25,61(2):453-461.