Thalidomide-O-amido-C8-NH2 hydrochloride

Description: Thalidomide-O-amido-C8-NH2 hydrochloride is a synthetic conjugate of an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker. It can be utilized in the synthesis of PROTACs[1]. Target: Others. Smiles: O=C(NCCCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl. References: James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.