Thalidomide-NH-PEG7

Description: Thalidomide-NH-PEG7 is a synthesized conjugate of an E3 ligase ligand and linker, intended for use in antibody-drug conjugates (ADCs). It can be attached to a protein ligand via a linker to form PROTAC iRucaparib-AP6, a highly selective degrader of PARP1[1]. Target: Others. Smiles: OCCOCCOCCO CCOCCOCCOC CNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O. References: Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec,15(12):1223-1231.