TH301

TH301 is a stabilizer of cryptochrome circadian regulator 2 (CRY2). It selectively stabilizes CRY2 over CRY1 in a degradation assay using HEK293 cells expressing CRY reporters at 0. to 10 µM. TH301 lengthens the circadian period in wild-type but not Cry2-/- mouse fibroblasts. It enhances rosiglitazone-dependent upregulation of the brown adipose tissue-specific genes Ucp1, Cidea, and Kcnk3 in primary mouse stromal vascular fractions. InChI: InChI=1S/C24H24ClN3O4S/c1-32-19-10-8-18(9-11-19)28-22(20-14-33(30,31)15-21(20)27-28)26-23(29)24(12-2-3-13-24)16-4-6-17(25)7-5-16/h4-11H,2-3,12-15H2,1H3,(H,26,29), InChIKey: DDCUCVXSGYHWRJ-UHFFFAOYSA-N, SMILES: O=C(C1(CCCC1)C2=CC=C(C=C2)Cl)NC3=C4C(CS(=O)(C4)=O)=NN3C5=CC=C(C=C5)OC