Tetrodotoxin (citrate free)

Tetrodotoxin (citrate free)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay14963-1 1 mg -

6 - 10 Werktage*

316,00 €
 
TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current... mehr
Produktinformationen "Tetrodotoxin (citrate free)"
TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials. It inhibits the NaV current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley's classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the NaV current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain.Formal Name: (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol. CAS Number: 4368-28-9. Synonyms: Araregai Toxin, Maculotoxin, Tectin, TTX. Molecular Formula: C11H17N3O8. Formula Weight: 319.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acidic Buffer (pH 4.8): 3 mM. SMILES: NC1=N[C@H](O)[C@@]2([H])[C@]3([H])[C@](CO)(O)[C@]([H])([C@@]4([H])O)O[C@@](O)(O3)[C@@H](O)[C@@]24N1. InChi Code: InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1. InChi Key: CFMYXEVWODSLAX-QOZOJKKESA-N.
Schlagworte: Araregai Toxin, Maculotoxin, Tectin, TTX, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol
Hersteller: Cayman Chemical
Hersteller-Nr: 14963

Eigenschaften

Anwendung: NaV channel blocking
MW: 319.3 D
Formel: C11H17N3O8
Reinheit: >98%
Format: Solid

Datenbank Information

CAS : 4368-28-9| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H300, H310, H330
P-Sätze: P260, P262, P264, P270, P271, P280, P284, P320, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P405, P403+P233, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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