Telocinobufagin

Description: 1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice challenged with live S. typhimurium. 3. Telocinobufagin has immunomodulatory activity, can enhance a Th1 immune response to control intracellular infections, could be developed as a novel immunotherapeutic agent to treat cancer and other immune-mediated diseases. Target: Others. Smiles: [H][C@@]12CC[C@]3(O)C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@]21O)c1ccc(=O)oc1. References: Wu S C , Fu B D , Shen H Q , et al. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection[J]. International Immunopharmacology, 2015, 25(2):353-362.