Telbivudine

Telbivudine is a beta-L-nucleoside analog of thymidine (Cay-20519) that has antiviral activity. It is active against hepatitis B virus (HBV) in 2.2.15 cells (EC50 = 0.19 µM). Telbivudine is selective for HBV over HIV-1, herpes simplex virus-1 (HSV-1), HSV-2, and influenza A and B (EC50s = >100 µM). It reduces serum viral load in a woodchuck model of chronic HBV infection in a dose-dependent manner. Formulations containing telbivudine have been used in the treatment of chronic HBV infection.Formal Name: 1-(2-deoxy-beta-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione. CAS Number: 3424-98-4. Synonyms: 2'-deoxy-L-Thymidine, L-Deoxythymidine, NV 02B, beta-L-Thymidine. Molecular Formula: C10H14N2O5. Formula Weight: 242.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 267 nm. SMILES: O=C(C(C)=CN1[C@H]2O[C@@H](CO)[C@H](O)C2)N([H])C1=O. InChi Code: InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1. InChi Key: IQFYYKKMVGJFEH-CSMHCCOUSA-N.