TCS 2210

TCS 2210 is a small molecule inducer of neuronal differentiation. It increases expression of the neuronal markers beta-III tubulin and neuron-specific enolase (NSE) and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells. TCS 2210 (20 µM per day for two days) converts >95% of a rat mesenchymal stem cell (MSC) population to a neuronal phenotype that exhibits potassium outward currents and increased expression of beta-III tubulin and NSE as well as the cholinergic genes CHRNA2, CHRNAB, and CHRM4.Formal Name: 1,2-dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide. CAS Number: 1201916-31-5. Molecular Formula: C18H17N3O3. Formula Weight: 323.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 5 mg/ml. SMILES: O=C(NO)C1=CC=C(NC(C(CCCC2=CC=CC=C2)=N3)=O)C3=C1. InChi Code: InChI=1S/C18H17N3O3/c22-17(21-24)13-9-10-14-16(11-13)19-15(18(23)20-14)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-11,24H,4,7-8H2,(H,20,23)(H,21,22). InChi Key: ZOFZKGFBKISZRI-UHFFFAOYSA-N.