Tasimelteon-d5

Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon (Cay-23546) by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors (Kis = 0.304 and 0.069 nM, respectively, in NIH3T3 cells expressing the recombinant human receptors) over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.Formal Name: N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-propanamide-2,2,3,3,3-d5. CAS Number: 1962124-51-1. Synonyms: BMS 214778-d5. Molecular Formula: C15H14D5NO2. Formula Weight: 250.4. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMF: soluble, DMSO: soluble, Methanol: soluble. SMILES: O=C(C([2H])([2H])C([2H])([2H])[2H])NC[C@@H]1C[C@@]1([H])C2=C3C(OCC3)=CC=C2. InChi Code: InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1/i1D3,2D2. InChi Key: PTOIAAWZLUQTIO-WILSWDKCSA-N.