Taraxasterol Acetate

Taraxasterol acetate is a pentacyclic triterpene that has been found in P. sagittalis and has diverse biological activities. It reduces the production of reactive oxygen species (ROS) and Hsp72 induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in isolated human neutrophils when used at concentrations of 10 and 100 µM and increases Hsp72 production in unstimulated isolated human neutrophils at 100 µM. Taraxasterol acetate (50 µg/ml) reduces protein levels of the E3 ubiquitin ligase RNF31 and increases levels of the autophagy marker LC3-I/II in HCT116 and SW480 cells. Topical administration of taraxasterol acetate (46 µg/ear) reduces ear edema induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607), croton oil, or PMA in mice.Formal Name: (3beta,18alpha,19alpha)-urs-20(30)-en-3-ol, 3-acetate. CAS Number: 6426-43-3. Synonyms: NSC 401400, Taraxasteryl Acetate. Molecular Formula: C32H52O2. Formula Weight: 468.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 0.1 mg/ml (heat/sonication). SMILES: C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C)=O)C)([H])CC2)C)([H])[C@]5([H])[C@@](CC3)(CCC([C@H]5C)=C)C)C. InChi Code: InChI=1S/C32H52O2/c1-20-12-15-29(6)18-19-31(8)23(27(29)21(20)2)10-11-25-30(7)16-14-26(34-22(3)33)28(4,5)24(30)13-17-32(25,31)9/h21,23-27H,1,10-19H2,2-9H3/t21-,23-,24+,25-,26+,27-,29-,30+,31-,32-/m1/s1. InChi Key: SFEUTIOWNUGQMZ-ZHLOSDGBSA-N. Origin: Plant/Inula britannica.